×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
[FMS-like tyrosine kinase 3 gene mutations in acute myeloid leukemia].
19840437 2009
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
15256420 2004
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.
22504184 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.
22504184 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia.
23714533 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
The other novel mutation, FLT3 K663Q, is the first AML -associated gain-of-function mutation located outside the JM and AL domains.
16990784 2006
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia.
23783394 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.
22368270 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations.
17889720 2007
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant.
16091740 2005
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies.
24619500 2014
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Recurring mutations found by sequencing an acute myeloid leukemia genome.
19657110 2009
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations.
16573742 2006
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia.
23321257 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968 2014
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968 2014
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways.
17047150 2007
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia.
15863200 2005
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.
16410449 2006
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3.
20733134 2010
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Novel observation of three FLT3 codons mutated in tandem in an elderly acute myeloid leukaemia patient.
16371029 2006
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.
14604974 2004
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Mutational landscape of AML with normal cytogenetics: biological and clinical implications.
23261068 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
MicroRNAs in liver disease.
22504185 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Impact of FLT3 mutations and secondary cytogenetic changes on the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with a single agent arsenic trioxide regimen.
17606455 2007